Myocardial Impact of NHE1 Regulation by Sildenafil
The cardiac Na+/H+ exchanger (NHE1) is a membrane glycoprotein fundamental for proper cell functioning due its multiple housekeeping tasks, including regulation of intracellular pH, Na+ concentration, and cell volume.In the heart, hyperactivation of NHE1 has been linked to the development of different pathologies.Several studies in animal models th